In the early eighth century BCE, the Neo-Assyrian Empire conquered the Northern Kingdom of Israel, from whence it has been said that ten of the twelve ancient tribes of Israel were deported and assimilated. These tribes are now lost to history, with a variety of folktales, legends, and theories about their fates having come about since that time. Some are told from the point of view of those who regard themselves as members of a lost tribe, while others are told from an outside perspective in order to make a case for self-serving outcomes.

Framed in the context of a gallery exhibition, "lost tribes" weaves together stories from the Assyrian conquest to the present day, tracing a world history of assimilation and dominance; of cultural conquest, annihilation, and survival. The performance incorporates choreography by Kai Hazelwood, production design by Leslie K. Gray, and a live percussion score composed by Michael Skloff, created in collaboration with Emilia Moscoso Borja and Alex Shaw. The production is written and directed by theatre dybbuk's artistic director, Aaron Henne, and developed with the ensemble.